After obtaining her bachelor of arts degree from Johns Hopkins, Bisrat served as a Fulbright Fellow in Eritrea, East Africa. She obtained her Medical and Public Health degrees at Emory University and completed an Internal Medicine residency at Johns Hopkins Hospital. Bisrat worked as an Epidemic Intelligence Service Officer at the Centers for Disease Control and Prevention (CDC), where she investigated tuberculosis outbreaks both in the U.S. and abroad. Bisrat then completed an Infectious Disease Fellowship at Weill Cornell Medical College in New York City. Her research interests focused on understanding predictors for poor clinical outcomes among those infected with HIV/ AIDS, particularly racial/ethnic minorities and women. She conducted this research as Assistant Professor of Medicine at Cornell and subsequently joined the Bureau of HIV at the New York City Health Department. She also served as interim Assistant Commissioner for the Bureau of HIV, during which time she launched an HIV prevention program focused on women. She has maintained her academic appointments at Cornell and has managed patients in the Infectious Disease clinic. As the Associate Director for Pfizer’s Vaccine Clinical Research & Development Program, Bisrat played a key role on one of the teams that  brought a COVID-19 vaccine to the public.